Gene regulation by cell-cell fusion in skeletal myogenesis.

【Background】 Myogenesis occurs not only at the stage of embryonic development but also during muscle repair in adults. Recently discovered transmembrane protein Myomixer (Mymx) initiates myogenesis by executing cell-cell fusion, although the physiological significance of Mymx-dependent cell fusion on muscle cell differentiation is not yet clear. The current study aims to elucidate the role of Mymx on muscle cell gene expression to understand the physiological importance of cell-cell fusion on myogenesis.