Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression
Saudi Pharmaceutical Journal（2022）
Abstract
•GM administration upregulated megalin and ClC-5 protein expressions.•Concurrent treatment with MLK downregulated ClC-5 protein expression.•Interference with ClC-5 by MLK reduced megalin expression.•MLK reduced renal uptake of FITC-BSA indicating impaired endocytic function.•MLK regulated p-AKT1/cleaved caspase-3 apoptotic pathway and kidney functions.
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Key words
Gentamicin endocytosis,Megalin,Chloride channel-5,Montelukast,Apoptosis
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