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Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 + Hematopoietic Progenitor Cells from Apoptosis

Meaghan H. Hancock,Lindsey B. Crawford,Wilma Perez,Hillary M. Struthers,Jennifer Mitchell,Patrizia Caposio

mSphere（2021）

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Abstract
Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34 + hematopoietic progenitor cells (HPCs) and periodically reactivate to cause disease in the absence of an intact immune system.
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