Elucidation of early markers in Insulin resistance Diabetes patients of Kashmir Valley

Diabetes Mellitus Type 2 (T2DM) is a complex, non-communicable disease. It is the biggest cause of death in children under the age of five in the world. Inflammatory cytokines have been shown to increase insulin resistance and, as a result, T2DM. The goal of this study was to look at the involvement of inflammatory mediators such as Tumor Necrosis Factor (TNF-) and White Blood Cells (WBCs) in mobilizing biological molecules, particularly those of an immunological origin and its possible role in the Insulin resistance. This study included 520 participants, 260 of whom had T2DM and 260 of whom were healthy controls. TNF-a (Tumor Necrosis Factor-a) concentrations in the blood were analysed using an ELISA approach, WBC count was determined using a Sysmax (Germany) hematology analyzer, and biochemical and immunoassay parameters were determined using fully automatic analyzers. T2DM patients had higher levels of potential pro-inflammatory cytokine (TNF-), as well as (WBC's).