Optical resolution of 1,16-dihydroxytetraphenylene by chiral gold(III) complexation and its applications as chiral ligands in asymmetric catalysis
CHEMICAL SCIENCE(2022)
摘要
We report herein a novel approach involving optical resolution of (+/-)-1,16-dihydroxytetraphenylene (DHTP) by chiral gold(III) complexation. This method features several key advantages, i.e., recyclability of chiral resolution reagents, feasibility of scaling up to gram quantities, and operational simplicity. On the basis of this method, which led to optically pure DHTP, a library of 2,15-diaryl (S)-DHTPs and several (S)-DHTP-derived phosphoramidite ligands were synthesized. Finally, the superior performance of a (S)-DHTP phosphoramidite ligand was demonstrated by efficient iridium-catalyzed asymmetric allylic alkynylation reactions.
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关键词
Chiral Ligands
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