Venetoclax: Uma Nova Esperança para o Doente Idoso com Leucemia Mielóide Aguda
Acta Médica Portuguesa(2022)
Abstract
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemotherapy, with frequent need of transfusion of red cell concentrates. The authors present, to the best of their knowledge, the first patient in Portugal with AML-MRC treated with an hypomethylating agent, azacytidine, and a BCL2 inhibitor (venetoclax), and that association was essential in the treatment and overall survival, which was much higher than expected.
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Key words
Compostos Bicíclicos Heterocíclicos com Pontes,Idoso,Leucemia Mielóide Aguda/tratamento formacológico
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