Research on Early Warning of Ischemic Stroke Based on Atherosclerosis Index Combined with Serum Markers

Abstract Background Ischemic stroke is a serious public health problem worldwide, threatening human life and health. Atherosclerosis is the cause of stroke. At present, there are few selective indexes that can be used to evaluate atherosclerosis in clinical, mainly relying on the atherosclerotic index. Disturbance of lipid metabolism is considered to be a key event leading to ischemic stroke. Aims The purpose of this study is to discover potential biomarkers in the serum of atherosclerosis-induced ischemic stroke, combined with atherosclerosis index to provide early warning for the diagnosis of ischemic stroke. Methods In this study, we used non-targeted metabolomics based on Ultra-high performance liquid chromatography -Quadrupole Time-Of-Flight Mass Spectrometry(UPLC-Q/TOF-MS) to measure the changes in serum metabolites in a group of patients with ischemic stroke. In order to verify the reproducibility of candidate biomarkers in the population, we expanded the sample size. Results Five metabolites were identified, including SM (18:0/14:0), 1-Methylpyrrolinium, PC (18:0/18:0), LysoPC (18:0/0:0) and PC (18: 2/18:2), the combination of five metabolic markers has good diagnostic and predictive ability, and the change level of these metabolites is significantly related to IS. Our results also indicate that changes in glycerophospholipid metabolism may indicate an early risk of IS development. Conclusion These findings may contribute to the development of new diagnostic methods of potential biomarkers in serum combined with atherosclerosis index, thereby providing early warning for the diagnosis of atherosclerosis-induced ischemic stroke, and may provide a pathogenesis of IS New insights.