Quantitative and Qualitative Analysis of Healthy Skin by Anatomic Site Utilizing Optical Coherence Tomography and Attenuation Coefficient

OCT is a promising imaging modality for the field of dermatology, but lack of research is hinders its use in everyday practice. Our study provides qualitative and quantitative analysis of healthy skin from various anatomic locations. Qualitative analysis showed identification of key structures including epidermis, dermis, and dermal epidermal junction (DEJ), as well as accessory structures. Quantitative analysis produced a characteristic absorption spectra of healthy skin, with a peaked intensity at stratum corneum, second peak at DEJ, and variations due to accessory structures. This analysis is valuable for OCTs use as a diagnostic aid in determining healthy vs pathologic skin.