M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.

Pooja Yadav,Panneerdoss Subbarayalu, Daisy Medina,Saif Nirzhor,Santosh Timilsina,Subapriya Rajamanickam,Vijay K Eedunuri,Yogesh Gupta,Siyuan Zheng,Nourhan Abdelfattah,Yufei Huang,Ratna Vadlamudi,Robert Hromas,Paul Meltzer,Peter Houghton,Yidong Chen,Manjeet K Rao

Cancer research（2022）

引用 29|浏览17

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摘要

RNA demethylase ALKBH5 upregulates USP22 and RNF40 to inhibit histone H2A ubiquitination and induces expression of key replication and DNA repair-associated genes, driving osteosarcoma progression.

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