Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial

•Individuals with type 2 diabetes are at increased risk of developing muscle weakness and sarcopenia•Genes expression atrogin-1 and MuRF-1 impairs the growth signalling pathway giving rise to muscle atrophy•IL-15 acts in the signalling pathway involved in the remodelling of the skeletal muscle•Recreational sports training and calorie restriction contribute to anti-aging effect on skeletal muscle in type 2 diabetes