Skeletal muscle gene expression in older adults with type 2 diabetes mellitus undergoing calorie-restricted diet and recreational sports training - a randomized clinical trial
Experimental Gerontology(2022)
摘要
•Individuals with type 2 diabetes are at increased risk of developing muscle weakness and sarcopenia•Genes expression atrogin-1 and MuRF-1 impairs the growth signalling pathway giving rise to muscle atrophy•IL-15 acts in the signalling pathway involved in the remodelling of the skeletal muscle•Recreational sports training and calorie restriction contribute to anti-aging effect on skeletal muscle in type 2 diabetes
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关键词
IL-15,MURF-1,TNF-α,IL-6,mRNA,mTOR
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