High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis.

Andrew D McCallum,Henry E Pertinez,Aaron P Chirambo,Irene Sheha,Madalitso Chasweka,Rose Malamba,Doris Shani,Alex Chitani,Jane E Mallewa,Jamilah Z Meghji,Jehan F Ghany,Elizabeth L Corbett, Stephen B Gordon,Geraint R Davies,Saye H Khoo,Derek J Sloan,Henry C Mwandumba

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2022）

Cited 2|Views14

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Abstract

Greater intrapulmonary drug exposure to rifampicin or isoniazid in the epithelial lining fluid was associated with more rapid bacillary clearance. Higher doses of rifampicin and isoniazid may result in sustained high intrapulmonary drug exposure, rapid bacillary clearance, shorter treatment duration and better treatment outcomes.

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Key words

antibiotics,antitubercular,pharmacodynamics,pharmacokinetics,tuberculosis

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