Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

Mitchel Otieno Okumu,James Mucunu Mbaria,Joseph Kangangi Gikunju,Paul Gichohi Mbuthia,Vincent Odongo Madadi,Francis Okumu Ochola, Kenneth Narotso Maloba, Joseph Gichuki Nderitu

TOXICON-X（2022）

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摘要

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).

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关键词

Snakebite,Naja ashei,Antivenoms,Neutralization,Potency

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