Fatty Acid beta-Oxidation in Kidney Diseases: Perspectives on Pathophysiological Mechanisms and Therapeutic Opportunities

The kidney is a highly metabolic organ and requires a large amount of ATP to maintain its filtration-reabsorption function, and mitochondrial fatty acid beta-oxidation serves as the main source of energy to meet its functional needs. Reduced and inefficient fatty acid beta-oxidation is thought to be a major mechanism contributing to kidney diseases, including acute kidney injury, chronic kidney disease and diabetic nephropathy. PPAR alpha, AMPK, sirtuins, HIF-1, and TGF-beta/SMAD3 activation have all been shown to play key roles in the regulation of fatty acid beta-oxidation in kidney diseases, and restoration of fatty acid beta-oxidation by modulation of these molecules can ameliorate the development of such diseases. Here, we disentangle the lipid metabolism regulation properties and potential mechanisms of mesenchymal stem cells and their extracellular vesicles, and emphasize the role of mesenchymal stem cells on lipid metabolism. This review aims to highlight the important role of fatty acid beta-oxidation in the progression of kidney diseases, and to explore the fatty acid beta-oxidation effects and therapeutic potential of mesenchymal stem cells for kidney diseases.