Annual Health Care Utilization and Cost of Granuloma Annulare in the United States, 2016 to 2019: A Cross-Sectional Study.

To the Editor: Granuloma annulare (GA) is a granulomatous skin condition characterized by annular erythematous papules and plaques and/or subcutaneous nodules, which may be localized or generalized. The annual incidence in the United States is approximately 0.04%. 1 Barbieri J.S. Rodriguez O. Rosenbach M. Margolis D. Incidence and prevalence of granuloma annulare in the United States. JAMA Dermatol. 2021; 157: 824-830 Crossref PubMed Scopus (17) Google Scholar GA is a heterogeneous disease, with some patients having minimal disease and some having more widespread disease; in case series, generalized GA has been reported in approximately 20% to 25% of all patients. 2 Piette E.W. Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016; 75: 467-479 Abstract Full Text Full Text PDF PubMed Scopus (104) Google Scholar Numerous treatment modalities are used; however, there is little consensus on appropriate treatment and even fewer well-controlled studies on treatment efficacy. 2 Piette E.W. Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016; 75: 467-479 Abstract Full Text Full Text PDF PubMed Scopus (104) Google Scholar In addition, little is known about current treatment usage patterns and associated health care costs.