Boosting effects of Cranberry and Cinnamaldehyde for pioglitazone amelioration of liver steatosis in rat via suppression of HIF-1α/Smad/β-catenin signaling

Mennatallah A. Ali,Shimaa A. Mahmoud,Adel Alkhedaide,Mohamed Mohamed Soliman,Tamer A. Al-Shafie,Yasser S. El-Sayed,Mustafa Shukry,Heba I. Ghamry,Samar S. Elblehi

Journal of Functional Foods（2022）

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摘要

•Cranberry and cinnamonaldehyde enhance pioglitazone treatment of NAFLD.•HIF-1α/TGF-β1/Smad/β-catenin signaling underlies the pioglitazone action.•Cranberry and Cinnamaldehyde boost biochemical and molecular gains of pioglitazone.

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关键词

High-fat diet,Liver steatosis,Hypoxia-inducible factor-1α,Transforming growth factor-β1,Smad2/3,β-catenin

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