Proliferative response avoids mutagenic effects of titanium dioxide (TiO2) nanoparticles in a zebrafish hepatocyte cell line

P.R. SIQUEIRA,Talita Laurie Lustosa do Carmo,Marina Marques Bonomo,Fabrício Aparecido dos Santos,Marisa Narciso Fernandes

Journal of Hazardous Materials Advances（2021）

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摘要

•Low doses of TiO2-NP induced proliferative response to replenish cell population.•Cells with genotoxic and mutagenic damage initiates programmed cell death.•ROS likely acts as inducers of cell death and proliferation.

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关键词

Apoptosis,cell proliferation,DNA damage,intracellular ROS production,membrane damage

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