New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II

Daniela A.S. Agostinho,Filipa Santos,José M.S.S. Esperança,Ana R.C. Duarte,Patrícia M. Reis

Journal of Ionic Liquids（2021）

引用 6|浏览11

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摘要

•New non-toxic dianionic ionic liquids were synthesized and characterized.•IC50 higher than 100 mM for fibroblasts L929 cells is achieved for new dianionic ILs.•log P of both drugs decreased in the presence of new dianionic ILs.

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关键词

Dianionic ionic liquids,Cytotoxicity,Drug delivery,Bioavailability,BCS Class II oral drugs

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