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A comprehensive model to predict severe acute graft-versus-host disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation

Meng-Zhu Shen,Shen-Da Hong,Rui Lou,Rui-Ze Chen,Xiao-Hui Zhang,Lan-Ping Xu,Yu Wang,Chen-Hua Yan,Huan Chen,Yu-Hong Chen, Wei Han,Feng-Rong Wang,Jing-Zhi Wang,Kai-Yan Liu,Xiao-Jun Huang,Xiao-Dong Mo

Experimental Hematology & Oncology（2022）

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Abstract
Background Acute graft-versus-host disease (aGVHD) remains the major cause of early mortality after haploidentical related donor (HID) hematopoietic stem cell transplantation (HSCT). We aimed to establish a comprehensive model which could predict severe aGVHD after HID HSCT. Methods Consecutive 470 acute leukemia patients receiving HID HSCT according to the protocol registered at https://clinicaltrials.gov (NCT03756675) were enrolled, 70
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Key words
Acute leukemia, Acute graft-versus-host disease, Haploidentical donor, Hematopoietic stem cell transplant, Predicted model
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