Intermittent parathyroid hormone increases stability and improves osseointegration of initially unstable implants.

Kevin Staats,Branden R Sosa,Emile-Victor Kuyl,Yingzhen Niu,Vincentius Suhardi,Kathleen Turajane,Reinhard Windhager,Matthew B Greenblatt,Lionel Ivashkiv,Mathias P G Bostrom,Xu Yang

Bone & joint research（2022）

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摘要

iPTH treatment mediated successful osseointegration and increased bone mechanical strength, despite initial implant instability. Clinically, this suggests that initially unstable implants may be osseointegrated with iPTH treatment. Cite this article: 2022;11(5):260-269.

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关键词

Aseptic loosening,Implant instability,Osseointegration,bone formation,fibrosis,micro-CT,murine model,osseointegration,parathyroid hormone,phosphate buffered saline,strengths,tibiae,titanium implants

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