TAK − 021, an inactivated Enterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups in human scavenger receptor B2 transgenic mice

•Hand, foot and mouth disease (HFMD) is frequently caused by enterovirus 71 (EV71)•HFMD is emerging as a major public health concern in the Asia-Pacific region.•TAK-021 is a candidate inactivated virus vaccine based on EV71 B2 sub-genogroup.•SCARB2-transgenic (SCARB2-tg) mice are susceptible to infection by multiple EV71 sub-genogroups.•TAK-021 is immunogenic and can protect against heterologous EV71 sub-genogroups in SCARB2-tg mice.