Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature

•Anillin-like protein Bud4 is required for virulence of basidiomycetous yeast, Cryptococcus neoformans.•C. neoformans lacking Bud4 is temperature sensitive and hypersensitive to agents disrupting plasma membrane and cell wall.•C. neoformans Bud4 contributes to re-organization of the septin complex at the mother-bud neck.•C. neoformans Bud4 is dispensable for bud site selection, in contrast to its Saccharomyces cerevisiae homologue.