Phosphine-catalyzed [3+2] annulation of beta-sulfonamido-substituted enones with trans-alpha-cyano-alpha,beta-unsaturated ketones for the synthesis of highly substituted pyrrolidines
RSC ADVANCES(2021)
摘要
To synthesize highly substituted pyrrolidines, we developed a phosphine-catalyzed [3 + 2] annulation of beta-sulfonamido-substituted enones with trans-alpha-cyano-alpha,beta-unsaturated ketones. We prepared a series of pyrrolidines under mild conditions with high yields and moderate-to-good diastereoselectivities. A catalytic mechanism for this reaction is suggested.
更多查看译文
关键词
ketones,synthesis,enones,phosphine-catalyzed,sulfonamido-substituted
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要