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A water-soluble fluorescent probe for real-time visualization of γ-glutamyl transpeptidase activity in living cells

Shiyuan Guo,Tianli Zhu,Rongchen Wang,Jinzhu Gao,Jie Sun,Zhirong Ou-Yang,Yingchao Liu,Xianfeng Gu,Chunchang Zhao

Bioorganic & Medicinal Chemistry Letters（2022）

Cited 3|Views3
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Abstract
A water-soluble fluorescent probe was designed for the real-time visualization of GGT activity. GGT can specifically catalyze the cleavage of γ-glutamyl linkage to release amino group, thus providing light-up fluorescence.
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Key words
Fluorescent probe,γ-Glutamyl transpeptidase,Water-soluble,Real-time visualization
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