Analytical and clinical validation of dried blood spot and volumetric absorptive microsampling for measurement of tacrolimus and creatinine after renal transplantation

Binu Susan Mathew,Sumith K Mathew,Blessed Winston Aruldhas,Ratna Prabha,Naveen Gangadharan,Vinoi George David,Santosh Varughese,George Tharayil John

Clinical Biochemistry（2022）

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摘要

•DBS and VAMS compared for measurement of tacrolimus and creatinine- shared extract.•Prediction equation from DBS and VAMS is validated in an independent cohort.•During patient validation, DBS similar to VAMS for tacrolimus, but VAMS superior for creatinine.•90 and 81% patients, VAMS: Whole blood agreement within 15% for tacrolimus and creatinine.

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关键词

VAMS,DBS,Tacrolimus,Creatinine,Whole blood,Clinical validation

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