Poorly differentiated eccrine carcinomas are associated with increased risk for poor outcomes

To the Editor: Eccrine carcinomas (ECs) are rare sweat gland tumors with increasing incidence. 1 Blake P.W. Bradford P.T. Devesa S.S. Toro J.R. Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol. 2010; 146: 625-632https://doi.org/10.1001/archdermatol.2010.105 Crossref PubMed Scopus (64) Google Scholar While 10-year survival rates are estimated to be 61%, disease-specific death (DSD) is only 3%. 2 Gopinath S. Giambarberi L. Patil S. Chamberlain R.S. Characteristics and survival of patients with eccrine carcinoma: a cohort study. J Am Acad Dermatol. 2016; 75: 215-217https://doi.org/10.1016/j.jaad.2016.01.029 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar There are few published cohort studies evaluating risk factors associated with poor outcomes. 2 Gopinath S. Giambarberi L. Patil S. Chamberlain R.S. Characteristics and survival of patients with eccrine carcinoma: a cohort study. J Am Acad Dermatol. 2016; 75: 215-217https://doi.org/10.1016/j.jaad.2016.01.029 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar This is the first cohort study to examine which histological factors are associated with an increased risk for poor outcomes in EC.