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UPFRONT MOLECULAR TARGETED THERAPY FOR THE TREATMENT OF BRAF-MUTANT PEDIATRIC HIGH-GRADE GLIOMA

Tom Rosenberg,Kee Kiat Yeo,Audrey Mauguen,Sanda Alexandrescu,Sanjay P Prabhu,Jessica W Tsai,Seth Malinowski,Mrinal Joshirao, Karishma Parikh,Sameer Farouk Sait,Marc K Rosenblum,Jamal K Benhamida,George Michaiel,Hung N Tran,Sonika Dahiya,Kara Kachurak,Gregory K Friedman,Julie I Krystal, Michael A Huang,Ashley S Margol,Karen D Wright,Dolly Aguilera,Tobey J MacDonald,Susan N Chi,Matthias A Karajannis

NEURO-ONCOLOGY（2022）

Cited 13|Views43
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Abstract
Upfront targeted therapy for patients with BRAF-mutant pHGG is feasible and effective, with superior clinical outcomes compared to historical data. This promising treatment paradigm is currently being evaluated prospectively in the Children's Oncology Group ACNS1723 clinical trial.
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Key words
BRAF,high-grade glioma,pediatrics,targeted therapy,treatment outcome
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