Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Shania M Corry,Amy Mb McCorry,Tamsin Rm Lannagan,Niamh A Leonard,Natalie C Fisher,Ryan M Byrne,Petros Tsantoulis,Xabier Cortes-Lavaud,Raheleh Amirkhah,Keara L Redmond,Aoife J McCooey,Sudhir B Malla,Emily Rogan,Svetlana Sakhnevych,Michael A Gillespie,Mark White,Susan D Richman,Rene-Filip Jackstadt,Andrew D Campbell,Sarah Maguire,Simon S McDade,Daniel B Longley,Maurice B Loughrey,Helen G Coleman,Emma M Kerr,Sabine Tejpar,Timothy Maughan,Simon J Leedham,Donna M Small,Aideen E Ryan,Owen J Sansom,Mark Lawler,Philip D Dunne Gut（2022）
摘要
This study reveals new biological insight that offers a novel therapeutic option to reduce relapse rates in patients with the worst prognosis CC.
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ADJUVANT TREATMENT,CANCER,COLON CARCINOGENESIS,COLORECTAL CANCER
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