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Treatment of Orbital Desmoid-type Fibromatosis With Sorafenib

Elaine M Downie, Christina E Amend, Alexander Miranda,Cat N Burkat

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY(2022)

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摘要
Desmoid-type tibromatosis is a rare tumor, particularly in the orbit, with fewer than 10 cases of primary orbital destnoid-type fibromatosis reported in the literature. The authors present a case of an infant who presented with rapid onset of OD proptosis, disc edema, and hyperopic shift who was found to have a retrobulbar desmoid-type fibro-matosis. After initial biopsy, due to risk of vision loss with complete excision, the tumor was treated with sorafenib, a tyrosine kinase inhibitor. During the course of treatment with sorafenib, the tumor stabilized and then regressed in size. To the authors' knowledge, this Is the first reported case of orbital desmoid-type fibromatosis to be treated with sorafenib.
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关键词
sorafenib,treatment,desmoid-type
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