Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Andrew Muranyi,Tobias Ammer,Anna Kechter,Vijay P S Rawat,Amit U Sinha,Irene Gonzalez-Menendez,Leticia Quintanilla-Martinez,Anca Azoitei,Cagatay Günes,Annalisa Mupo,George S Vassiliou,Shiva Bamezai,Christian Buske

Blood Advances（2023）

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摘要

•NPM1 haploinsufficiency in collaboration with MEIS1 overexpression is sufficient to induce complete AML in mice.•The MEIS1-SMC4 axis is a potential therapeutic target in NPM1c AML.

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meis1,aml

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