SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

Tobias Boettler,Benedikt Csernalabics,Henrike Salié,Hendrik Luxenburger,Lara Wischer,Elahe Salimi Alizei,Katharina Zoldan,Laurenz Krimmel,Peter Bronsert,Marius Schwabenland,Marco Prinz,Carolin Mogler,Christoph Neumann-Haefelin,Robert Thimme,Maike Hofmann,Bertram Bengsch

Journal of Hepatology（2022）

引用 52|浏览24

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摘要

•Identification of immune correlates in a case of mRNA vaccine-associated autoimmune hepatitis.•Imaging mass cytometry identifies intrahepatic panlobular enrichment of activated cytotoxic CD8 T cells.•Flow cytometry identifies intrahepatic enrichment of activated CD8 T cells with SARS-CoV-2-specificity.•Peripheral SARS-CoV-2-specific CD8 T-cell activation correlates with ALT levels.

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关键词

COVID-19,Vaccination,Autoimmune hepatitis,Virus-specific T cell,CD8+ T cell,Immunosuppression

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