Direct synthesis of triazines from alcohols and amidines using supported Pt nanoparticle catalysts via the acceptorless dehydrogenative methodology

We report a cost-effective, green, and acceptorless dehydrogenative one-pot synthesis of triazines from primary alcohols and amidines using an alumina-supported Pt nanoparticle catalyst (Pt/Al2O3). This reaction proceeds with high atom efficiency via sequential dehydrogenation, condensation, and dehydration steps, where the cyclization of the components undergoes selective C-C and C-N bond formations. The Pt/Al2O3 catalyst is reusable, and the process gives good to excellent yields (up to 93% isolated yield) for triazine synthesis. The use of readily available starting materials, high atom economy, the recyclability of the catalyst, and generation of minimum byproducts renders this an environmentally benign reaction system.