Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2022)

引用 9|浏览20
暂无评分
摘要
Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca2+ release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2.
更多
查看译文
关键词
ryanodine receptor,RyR,ryanopathies,congestive heart failure,catecholaminergic polymorphic ventricular tachycardia,CPVT,dantrolene,flecainide,carvedilol
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要