CLP1-dependent premature transcription termination opposes neurodegeneration.

Michal R Gdula, Magda Kopczyńska,Upasana Saha,Kinga Kamieniarz-Gdula

Neuron（2022）

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摘要

Usage of alternative mRNA 3' ends has profound functional consequences, particularly in the nervous system. In this issue of Neuron, LaForce et al. (2022) dissect the effect of CLP1 on mRNA 3' end diversity in motor neuron models of neurodegeneration.

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