Facile Preparation of a Thienoisoindigo-Based Nanoscale Covalent Organic Framework with Robust Photothermal Activity for Cancer Therapy
ACS APPLIED MATERIALS & INTERFACES(2022)
摘要
The covalent organic frameworks (COFs) so far are usually built with small aromatic subunits, which makes their absorption spectra mainly located in the high-energy part of the visible region. In this work, we have developed a COF with a low band gap by integrating electron-deficient thienoisoindigo and electron-rich triphenylamine. The intramolecular charge-transfer effect combining the extended length of the pi-conjugated backbone of COF endow it with broad absorption even to the second near-infrared region. After optimizing the solvent, a uniform size and colloidal stable COF is obtained. Benefiting from the coplanar structure of the monomer, this COF achieves a considerable photothermal conversion efficiency (PCE) of 48.2%. With these advantages, it displays convincing cancer cell killing effect upon laser irradiation in vitro or in vivo. This work provides a simple and practical method to acquire promising a COF-based phototherapy reagent that is applied in biomedicine field.
更多查看译文
关键词
thienoisoindigo,covalent organic framework,photothermal therapy,size controllable,donor-acceptor structure
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要