Discontinuation of adjuvant endocrine therapy and impact on quality of life and functional status in older patients with breast cancer

Annelieke A Lemij,Nienke A de Glas,Marloes G M Derks,Esther Bastiaannet,Jos W S Merkus,Titia E Lans,Carmen C van der Pol,Thijs van Dalen,Annelie J E Vulink,Leander van Gerven,Onno R Guicherit,Eugenie M H Linthorst-Niers,Frederiek van den Bos,Judith R Kroep,Gerrit Jan Liefers,Johanneke E A Portielje

Journal of Geriatric Oncology（2021）

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摘要

A large proportion of older patients discontinue adjuvant endocrine treatment within 2 years after initiation, but geriatric characteristics are not predictive of early discontinuation of treatment. Discontinuation of adjuvant endocrine therapy did not positively affect QoL and functional status, which implies that the observed poorer QoL in this group is probably not caused by adverse effects of endocrine therapy.

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关键词

Breast cancer,Endocrine therapy,Geriatric assessment,Older patients

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