Cytokine profile, ferritin and multi-visceral involvement characterize macrophage activation syndrome during adult-onset Still's disease.

Piero Ruscitti,Francesco Ursini,Onorina Berardicurti,Francesco Masedu,Emanuele Bozzalla Cassione,Susanna Naldi,Ilenia Di Cola,Claudia Di Muzio,Ludovico De Stefano,Elena Di Nino,Luca Navarini,Marta Vomero,Serena Bugatti,Marco Valenti,Erminia Mariani,Annamaria Iagnocco,Carlomaurizio Montecucco,Roberto Giacomelli,Paola Cipriani

Rheumatology (Oxford, England)（2022）

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摘要

A multidimensional characterization of AOSD patients suggested that IFN-γ, IL-10, ferritin and systemic score discriminated the occurrence of cytokine storm syndrome associated with MAS. The inflammatory milieu of AOSD and MAS may be related to a signature of circulating immune cells. Finally, our results about IRGs reinforced the role of IFN-γ in these patients.

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关键词

adult-onset Still’s disease,cytokine storm syndrome,macrophage activation syndrome

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