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Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response

Junfeng Zhu,Ying Xu, Zheng Li,Shanshan Liu,Wenda Fu,Yesheng Wei

International Immunopharmacology（2022）

Cited 8|Views13
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Abstract
•IL-36β expression was elevated in the colon of mice with DSS-induced colitis.•rIL-36β administration aggravates DSS-induced colitis in mice.•rIL-36β treatment promotes Th2 cell response in mice with DSS-induced colitis.•rIL-36β treatment suppresses Foxp3+ Treg response in mice with DSS-induced colitis.
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Key words
Interleukin-36β,Dextran sulfate sodium,Colitis,Th2 cell,Foxp3+ regulatory T cell
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