Critical review on disposition of chlorinated paraffins in animals and humans

•Based on human and animal data, the review presents ADME data on CPs, and suggests further research needs.•Thousands of CP isomers are absorbed and accumulated in humans and wildlife.•Numerous CP metabolite reactions are suggested, of which chain shortening (CO2) and GSH conjugates are shown in vivo.•CPs are of major health concern but properties of CP metabolites, including their toxicity, are still unknown.•Future metabolism and toxicity studies of CPs are strongly encouraged.