Increased HBV Coinfection and Decreased IFN-gamma-Producing HBV-Specific CD8+T Cell Numbers During HIV Disease Progression

Objective:& nbsp;To investigate the characteristics and mechanism of the dynamics of HBV infection with the progression of HIV disease and to explore the different responses of T lymphocytes to HBV in HIV patients in different stages of disease.& nbsp;Methods:& nbsp;We compared the rates and characteristics of HBV coinfection between 372 early HIV-infected and 306 chronically HIV-infected men who have sex with men (MSM) in the Beijing Youan Hospital from October 2006 to November 2014. We further analysed IFN-gamma-producing HBV-specific CD8+ T cells in 15 early HIV-infected individuals and 20 chronic HIV-infected individuals with HBV coinfection.& nbsp;Results:& nbsp;Twenty-three HBsAg-positive cases were detected among the 372 early HIV-infected patients of this cohort, and the coinfection rate was 6.18%, while 35 HBsAg-positive cases were detected among the 306 chronically HIV-infected patients, with a coinfection rate of 11.44%. The coinfection rate of the chronically HIV-infected patients was significantly higher than that of the early-infected patients (p=0.0005). The median CD4+ T cell count in the early HIV infection patients was 445 cells/mu L (196-1,030 cells/mu L), which was higher than that in the chronic HIV infection patients [358 cells/mu L (17-783 cells/mu L)] (p < 0.001). The proportion of IFN-gamma-producing CD8+ T cells in early HIV-infected patients was significantly higher than that in chronically HIV-infected patients.& nbsp;Conclusion:& nbsp;The coinfection rate of HBV in HIV patients increases with HIV disease progression, which might be related to the decreased IFN-gamma-producing HBV-specific CD8+ T cell numbers. The closely monitored HBV serum markers from the early stage of HIV infection are warranted.