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Exploring the pharmacological components and effective mechanism of Mori Folium against periodontitis using network pharmacology and molecular docking

Zeyu Wu,Xiaowei Ji,Chao Shan,Jie Song,Jin Zhao

Archives of Oral Biology（2022）

Cited 5|Views7
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Abstract
•The mechanism of the Mori Folium against periodontitis via network pharmacology and molecular docking analysis.•Quercetin, Moracin D, E, G, H, B are the main components of Mori Folium for the prevention and treatment of periodontitis.•Targets are mainly enriched in response to bacteria and lipopolysaccharides, angiogenesis, and reactive oxygen species.
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A. actinomycetemcomitans,ADME,AGEs,AKT1,ALB,ALP,BP,CC,DL,EGF,ETCM,GO,IL6,IL10,KEGG,MF,MIF,MMP9,OB,P. gingivalis,PI3K,PPI,PTGS2,RA,RANKL,ROS,RUNX2,TCMSP,TGF,T. forsythia,TIMP3,TNF,TP53,VEGFA
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