Facilitative role of circPVT1 in osteogenic differentiation potentials of bone marrow mesenchymal stem cells from patients with osteoporosis through the miR-30d-5p/ITGB3 axis

Hongjian Tan,Yiwen Wang,Zehua Zou,Yufei Xing,Zuowei Shi,Kaifu Wang,Daming Dong

Tissue and Cell（2022）

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摘要

•Decreased expression of circPVT1 and ITGB3 was found in BMSCs of OP patients.•CircPVT1 induced osteogenic differentiation of BMSCs.•CircPVT1 negatively regulated miR-30d-5p.•ITGB3 was a potential target for miR-30d-5p.•CircPVT1 promoted osteogenic differentiation of BMSCs via miR-30d-5p-mediated ITGB3.

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关键词

Osteoporosis,CircPVT1,MiR-30d-5p,ITGB3,Osteogenic differentiation,Bone marrow mesenchymal stem cells,Competitive endogenous RNA

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