TSPAN31 regulates the proliferation, migration, and apoptosis of gastric cancer cells through the METTL1/CCT2 pathway
Translational Oncology(2022)
摘要
•TSPAN31 is rarely studied in human malignant tumors and a little study had explored its function and mechanism.•This study found that the expression level of TSPAN31 was related to the clinical characteristics and prognosis of patients with gastric cancer.•This study found that TSPAN31 can regulate the proliferation, migration and apoptosis of gastric cancer cells.•This study found that expression level of TSPAN31, METTL1 and CCT2 was positive correlation in gastric cancer cells.•This study found that down-regulation of TSPAN31 could be partially reversed the promoting effect of high expression of METTL1 or CCT2 on malignant phenotype of gastric cancer cells.
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关键词
Gastric cancer,TSPAN31,Cell proliferation,Cell migration
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