Differential Experience of Interdose Withdrawal During Long-Term Opioid Therapy and its Association With Patient and Treatment Characteristics: A Latent Class Analysis in Chronic Pain Population

•Research on opioid withdrawal lacks a person-centered approach.•Based on Latent Class Analysis, 3 patterns of opioid withdrawal were identified.•Latent classes included mild, moderate, and severe opioid withdrawal.•Nearly 60% of chronic pain patients experienced psychological withdrawal symptoms.•More severe withdrawal classes showed higher rates of problematic opioid use.