Post-Transplantation Day +100 Minimal Residual Disease Detection Rather Than Mixed Chimerism Predicts Relapses after Allogeneic Stem Cell Transplantation for Intermediate-Risk Acute Myelogenous Leukemia Patients Undergoing Transplantation in Complete Remission

Evgeny Klyuchnikov,Anita Badbaran,Radwan Massoud,Ulrike Fritzsche-Friedland,Petra Freiberger,Francis Ayuk,Christine Wolschke,Ulrike Bacher,Nicolaus Kröger

Transplantation and Cellular Therapy（2022）

引用 5|浏览5

暂无评分

摘要

•Full donor chimerism can mitigate the negative impact of pretransplantation minimal residual disease (MRD) positivity.•Quantitative real-time PCR-MRD is more predictive than multiparameter flow cytometry-MRD for post-transplantation relapse.•Mixed chimerism (MC) has limited predictive value for post-transplantation relapse.•MC without post-transplantation MRD is not associated with worse outcomes.

查看译文

关键词

Allogeneic hematopoietic stem cell transplantation,Minimal/measurable residual disease,Quantitative real-time PCR,Mixed chimerism,Multiparameter flow cytometry,Acute myelogenous leukemia

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要