[Coactivator p300-induced H3K27 acetylation mediates lipopolysaccharide-induced inflammatory mediator synthesis].

K Hu,X Cao, Y Li, L Liu, Y Chen,L Chen,M Huang,B Tan,H Yin

Nan fang yi ke da xue xue bao = Journal of Southern Medical University（2022）

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摘要

LPS can stimulate the synthesis of p300, whose binding to the promoter region of inflammatory genes c-myb facilitates the cohesion of p65 by inducing H3K27 acetylation, thus promoting the expression of the inflammatory genes.

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关键词

acetylation,inflammatory mediator,lipopolysaccharide,p300,synthesis

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