Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth

Lifeng Yang,Tara TeSlaa,Serina Ng,Michel Nofal,Lin Wang,Taijin Lan,Xianfeng Zeng,Alexis Cowan,Matthew McBride,Wenyun Lu,Shawn Davidson,Gaoyang Liang,Tae Gyu Oh,Michael Downes,Ronald Evans,Daniel Von Hoff,Jessie Yanxiang Guo,Haiyong Han,Joshua D Rabinowitz

Med（2022）

引用 24|浏览28

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摘要

•Ketogenic diet synergizes with classical chemotherapy to treat murine pancreas cancer•In response to ketosis, tumors suppress glucose use and induce 3-hydroxybutyrate use•Therapeutic benefit correlates with elevated tumor NADH/NAD ratio•Survival gain from chemotherapy is roughly tripled in the ketogenic diet condition

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关键词

ketogenic diet,pancreatic cancer,chemotherapy,ketone metabolism,NADH/NAD,reactive oxygen species

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