Inhibition of endocytic recycling of ACE2 by SARS-CoV-2 S protein partially explains multiple COVID-19 related diseases caused by ACE2 reduction.
The Journal of infection（2022）
Abstract
•Endocytic recycling of ACE2 is mediated by SNX27.•SARS-CoV-2 S protein associates with SNX27.•SARS-CoV-2 S inhibits the interaction between SNX27 and ACE2.•SARS-CoV-2 S reduces surface ACE2 by suppressing endocytic recycling of ACE2.
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