Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(2022)
摘要
Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition effect. Based on the comparative analysis of these compounds, we propose that Tschimganine has at least 2 targets: one extends the lifespan and the other inhibits growth.
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关键词
Tschimganine, Mochimganine, chronological lifespan, fission yeast
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