Catalytic asymmetric transformation of nitrones and allenes to dihydropyridoindoles via chiral N,N′-dioxide/cobalt(ii) catalysis
Chemical Communications(2022)
Abstract
A chiral N,N′-dioxide/cobalt(ii) complex catalytic system is developed to promote the multistep cascade reaction of α,β-unsaturated-N-aryl nitrones with allenes, giving a variety of chiral dihydropyridoindoles in moderate to good yields with excellent dr and ee values. Mechanistic studies support a [3+2] cycloaddition/[3,3]-rearrangement/retro-Mannich process.
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Key words
dihydropyridoindoles,catalytic asymmetric transformation,catalysis,nitrones,<i>n</i><i>n</i>′-dioxide/cobalt<scp>ii</scp>
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