FIP-nha, a fungal immunomodulatory protein from Nectria haematococca, induces apoptosis and autophagy in human gastric cancer cells via blocking the EGFR-mediated STAT3/Akt signaling pathway
Food Chemistry: Molecular Sciences(2022)
Abstract
•FIP-nha, a new FIP discovered beyond Basidiomycota, has been demonstrated a broad spectrum of antitumor activity and cell selectivity against human cancers.•FIP-nha inhibited the growth, induced apoptosis and autophagy of gastric cancer cells through competitively binding to EGFR with EGF to blocking the EGFR-mediated STAT3/Akt pathway.•FIP-nha may be a potential chemotherapy drug that targeted EGFR to treat human gastric cancer.
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Key words
FIP-nha,Gastric cancer,Apoptosis,Autophagy,EGFR,STAT3/Akt pathway
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